We focus on these in musculoskeletal system and highlight knowledge gaps in the literature regarding cellular and tissue crosstalk in bone, cartilage, and the bone marrow niche. Cellular senescence, stem cell exhaustion, mitochondrial dysfunction, epigenetic and intracellular communication changes are central pathways and recognized as associated and potentially causal in aging. Cellular hallmarks of aging are examined, as related to bone and the marrow microenvironment, and ways in which these might contribute to a variety of age-related perturbations in osteoblasts, osteocytes, marrow adipocytes, chondrocytes, osteoclasts, and their respective progenitors. That trabecular bone increases were achievable in both KO and WT, despite a difference in BMAT quantity/distribution, points to potential metabolic flexibility during exercise-induced skeletal anabolism.Īging induces alterations in bone structure and strength through a multitude of processes, exacerbating common aging- related diseases like osteoporosis and osteoarthritis. The presence and distribution of BMAT in SEIPIN KO, though lower than WT, is unexpected and points to a uniqueness of this depot. Notably, exercise increased trabecular BV/TV in both (+31%, KO-E vs KO, p=0.004 +14%, WT-E vs WT, p=0.006). Exercise reduced weight (-24% WT-E vs WT p<0.001) but not in KO.
Running distance, speed, and time were comparable in KO and WT. Bone via μCT was preserved in SEIPIN KO, though some quality parameters were attenuated. SEIPIN ablation’s most notable effect marrow adiposity was in the proximal femoral diaphysis (-56% KO vs WT, p=0.005), with relative preservation in KO-distal-femur. Bone marrow adipose tissue (BMAT), unlike white adipose, was measurable, although 40.5% lower in KO vs WT (p=0.0003) via 9.4T MRI/advanced image analysis. KO weighed 14% less than WT (p=0.01) and exhibited an absence of epididymal adipose tissue KO liver Plin1 via qPCR was 9-fold that of WT (p=0.04), consistent with steatosis. Male twelve-week-old B6 knockouts (KO) and wild type (WT) littermates were assigned six-weeks of voluntary, running exercise (E) versus non-exercise (N=5-8). We applied a mouse model of global deficiency of Bscl2 (SEIPIN), required for lipid droplet formation. Current archaeological fieldwork includes the French Mission to the Eastern Desert in Egypt and the Azoria Project on Crete.Exercise, typically beneficial for skeletal health, has not yet been studied in lipodystrophy, a condition characterized by paucity of white adipose tissue, with eventual diabetes, and steatosis. Classics is inherently multidisciplinary, drawing on various forms of evidence and modes of interpretation in order to understand the past, and to explore how later periods, including our own, have found classical antiquity meaningful, or in some cases have misused the classical tradition in ways we must now study with an unsparing eye.Ĭurrent graduate research and teaching include Homeric epic Aegean prehistory and protohistory Archaic poetry and Greek drama performance Greek topography and mortuary archaeology Greek and Roman historiography women and gender studies Hellenistic and Roman Near East and Egypt Hellenistic and Roman art religion, sacrifice, magic, and the underworld Roman comedy and satire Hellenistic, Republican and Augustan poetry the Second Sophistic paleography and Medieval Latin and the reception of the classical world. We study, write about, and teach the language, literature, history, art, and archaeology of the Greek and Roman world and its relevance to today.
The Department of Classics continues a long Carolina tradition of offering undergraduates and graduate students access to research by world-class faculty on many fascinating aspects of the ancient Greek, Roman, and broader Mediterranean worlds.
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